Custom service
Custom immunodepletion services
Recover the value of your complement sera with our proprietary antibody depletion service. We remove interfering antibodies while preserving complement activity for hSBA and other vaccine studies.
Hear from our community
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“Pel-Freez's IgG/IgM depleted human complement has been crucial for complement-dependent bactericidal assays in my lab. The material is of the highest quality, with minimal lot-to-lot variation. This reagent has saved us considerable time and expense.”
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“Thank you for the trial sample of antibody-depleted human complement. After running cell-dependent assays on both the liquid and lyophilized material, activity stayed fully comparable even when the lot shipped on cold packs rather than dry ice.”
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“Pel-Freez's IgG/IgM/IgA-depleted, heat-inactivated human serum worked well in our assay, and they were able to prepare a same-donor bridging batch with a small test aliquot before we committed to the full volume.”
From screening failures to assay-ready serum
Serum that fails qualification leaves you with costly, unusable material in an industry where every unit matters. Our proprietary antibody-depletion technology helps you reclaim samples by removing interfering IgG, IgM, and IgA while preserving complement activity.
Engineered for liter-scale production, we process samples from 500 mL to 5 L, followed by QC and CH50 testing. With our custom service, you can collaborate with our team to include additional analytes or tests tailored to your program.
Data spotlight: Antibody depletion rescues sera for hSBA
A large vaccine company contacted us for help after dozens of units of human complement failed hSBA screening due to high baseline antibody levels.
Using our bulk antibody depletion process, we converted their pooled sera into material suitable for use in hSBA. The client confirmed that the depleted complement was acceptable across multiple bacterial strains and test sera.
Waste less. Test smarter.
Our antibody depletion service turns unusable donor units into SBA-ready sera so you can:
- Save time and money: Reuse donor serum instead of sourcing new material.
- Improve assay success: Remove interfering antibodies to enable SBA testing across multiple bacterial strains.
- Maximize donor resources: Preserve complement function and extend the usefulness of every precious human donor unit.
Process Overview
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Discuss your project requirements
Outline your research goals with our team to create a custom depletion protocol.
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Submit your sample
Send us your remnant samples or previously tested donor units.
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Custom depletion and QC
We apply our proprietary technology to deplete IgG, IgM, and/or IgA and verify complement activity.
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Delivery to your lab
You receive SBA-ready sera for ongoing vaccine and therapeutic studies.
How is Pel-Freez Biologicals' antibody-depleted complement made?
What's the difference between antibody-depleted human complement (ADHC), heat-inactivated ADHC (ADHC-HI) and antibody-depleted human serum (ADHS)?
- ADHC (antibody-depleted human complement) keeps high complement potency for assays that need functional complement.
- ADHC-HI is the same material heat-inactivated and CH50 tested to confirm no complement activity, for applications that need the other serum components but not complement.
- ADHS (antibody-depleted human serum) starts from normal human serum that was not collected to preserve complement; it is neither heat-inactivated nor CH50 tested, and serves as a negative matrix for dilution, QC samples, or cell culture where complement would inhibit growth.
What sample volumes can be processed for Pel-Freez Biologicals’ custom antibody-depletion service?
How is complement activity verified after custom antibody depletion?
Can you target specific antibodies for depletion?
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Tired of wasting valuable donor sera? We can help.
Partner with a proven supplier for consistent, complement-preserved serum at the scale your studies demand.