Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine synthesis, which makes it the field-standard marker for any neuron or cell that makes dopamine, norepinephrine, or epinephrine. If your work touches the nervous system, adrenal biology, or catecholamine signaling, there is a good chance TH is already on your antibody shelf.
Our anti-TH antibodies come in two host species for a reason. The rabbit polyclonal (P40101) is the workhorse for standard IHC, ICC, and western blot. The sheep polyclonal (P60101) is built for multi-label co-staining, so you can pair it with a rabbit- or mouse-host primary in the same tissue section without cross-reactivity.
Researchers use these antibodies for mapping catecholaminergic neurons across brain regions and species, validating reporter and Cre-driver transgenic lines, characterizing stem cell-derived neuronal populations, and standard IHC/ICC/WB workflows. Decades of consistent lot-to-lot performance, validated across species.
Originally shared on LinkedIn.