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  • IgG Depleted Single Donor Human Complement Lyophilized

IgG Depleted Single Donor Human Complement Lyophilized

Human serum is depleted of IgG antibodies, 0.2 micron filtered, aliquoted, frozen, and lyophilized.
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Specifications
Single Donor
Lyophilized Powder
-20°C or below
Assay development & validation, Immunoassays, Non-clinical & preclinical studies, R&D, Vaccine development
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Bulk Requirements for Human Serum
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 $64.00
Lead time on this item is currently: 2-4 Weeks

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Product Overview
Product Overview
Application: Assay development & validation, Immunoassays, Non-clinical & preclinical studies, R&D, Vaccine development
Storage Conditions: -20°C or below
Shipping Conditions: Cool packs
Species: Human
Application Notes: Suitable for functional antibody assays (SBA-Serum Bactericidal Assay, MOPA/OPA- Multiplexed /Opsonophagocytic Killing Assay) for vaccine evaluation. Complement components are extremely heat-sensitive; for best results, thaw complement on ice or in a cold water bath. Aliquots may be made and frozen at -70°C or below. Avoid multiple freeze-thaw cycles. When a working aliquot is thawed, do not re-freeze remaining complement, but discard it.
Guarantee: Product quality is guaranteed to meet Pel-Freez Biologicals’ specifications for 1 year from the date of receipt by the customer as long as the product is stored in accordance with the indicated storage conditions.
Testing: CH50: Report Residual IgG: <10% Moisture: <5% Serum tested negative for infectious disease per FDA guidelines.
Packaging: Glass vial
Product Attributes: Antibody Depleted, Lyophilized, Off-the-Clot (OTC)
Donor Sex: Either
Donor Type: Single Donor
Product Types: Complement
Physical State: Lyophilized Powder
Depletion Process: IgG Depleted
Source: OTC Serum
Product Applications
  • Assay development & validation
  • Opsonophagocytic assay
  • R&D
  • Serum bactericidal assay
  • Toxicology assays
  • Vaccine development

Product References

Salic acid protects nontypeable Haemophilus influenza from natural IgM and promotes survival in murine respiratory tract.

Jackson, M. D., Wong, S. M. & Akerley, B. J. Sialic acid protects nontypeable haemophilus influenzae from natural igm and promotes survival in murine respiratory tract. Infect. Immun. 89, (2021).
Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Shaughnessy, J. et al. Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae. Front. Immunol. 11, 2680 (2020).
Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

Parzych, E. M. et al. Synthetic dna delivery of an optimized and engineered monoclonal antibody provides rapid and prolonged protection against experimental gonococcal infection. MBio 12, 1–13 (2021).
Neisseria meningitidis urethritis outbreak isolates express a novel factor H binding protein variant that is a potential target of group B-directed meningococcal (MenB) …

Tzeng, Y. L. et al. Neisseria meningitidis urethritis outbreak isolates express a novel factor H binding protein variant that is a potential target of group B-Directed meningococcal (menb) vaccines. Infect. Immun. 88, (2020).
Vaccination with Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model

Fernandez, J. et al. Vaccination with Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model . J. Infect. Dis. (2021).
Preclinical efficacy of a lipooligosaccharide peptide mimic candidate gonococcal vaccine

Gulati, S. et al. Preclinical efficacy of a lipooligosaccharide peptide mimic candidate Gonococcal vaccine. MBio 10, (2019).
Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae

Gulati, S., Rice, P. A. & Ram, S. Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae. in Methods in Molecular Biology vol. 1997 267–280 (Humana Press Inc., 2019).
Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria

Shaughnessy, J. et al. Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae. Front. Immunol. 11, (2020).