https://www.pel-freez.com/blogs/news 2026-09-19T10:14:00-05:00 weekly https://www.pel-freez.com/blogs/blog 2026-10-05T12:00:01-05:00 weekly https://www.pel-freez.com/blogs/publications 2026-09-19T14:57:27-05:00 weekly https://www.pel-freez.com/blogs/blog/antibody-depleted-human-complement-weve-scaled-up-our-process 2026-09-15T10:18:17-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Picture1.jpg?v=1789168477 Antibody Depleted Human Complement: We’ve Scaled Up Our Process! Antibody Depleted Human Complement: We’ve Scaled Up Our Process! https://www.pel-freez.com/blogs/blog/baby-rabbit-complement-the-gold-standard-for-functional-antibody-assays 2026-09-17T10:00:13-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/qqq.jpg?v=1789168475 Baby Rabbit Complement: The Gold Standard for Functional Antibody Assays Baby Rabbit Complement: The Gold Standard for Functional Antibody Assays https://www.pel-freez.com/blogs/blog/choose-the-right-antibody-depleted-human-serum-for-your-vaccine-research 2026-09-17T10:00:13-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/antibody-depleted-human-serum-scaled.jpg?v=1789168473 Choose the right antibody-depleted human serum for your vaccine research Choose the right antibody-depleted human serum for your vaccine research https://www.pel-freez.com/blogs/news/join-us-at-medica-in-dusseldorf-germany 2026-09-15T10:18:17-05:00 weekly https://www.pel-freez.com/blogs/news/join-us-at-the-12th-international-symposium-on-pneumococci-and-pneumococcal-diseases 2026-09-15T18:56:00-05:00 weekly https://www.pel-freez.com/blogs/news/join-us-at-the-2022-world-vaccine-congress 2026-09-15T18:56:00-05:00 weekly https://www.pel-freez.com/blogs/blog/dont-waste-your-valuable-sera-samples 2026-09-17T10:00:14-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/laboratory-assistant-putting-test-tubes-image_e7fe1db8-d577-404e-a257-f8d632bb57ba.jpg?v=1789168476 Don’t waste your valuable sera samples! Don’t waste your valuable sera samples! https://www.pel-freez.com/blogs/blog/evaluate-vaccine-immunogenicity-with-opka 2026-09-17T20:50:00-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/vaccine-immunogenicity-with-OPKA.jpg?v=1789168472 Evaluate vaccine immunogenicity with OPKA Evaluate vaccine immunogenicity with OPKA https://www.pel-freez.com/blogs/blog/expanding-luminescence-based-sba-to-7-shigella-serotypes-with-pel-freez-baby-rabbit-complement 2026-09-17T10:00:14-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/GSK-Vaccines-Paper-image-scaled.jpg?v=1789168470 Expanding luminescence-based SBA to 7 Shigella serotypes with Pel-Freez baby rabbit complement Expanding luminescence-based SBA to 7 Shigella serotypes with Pel-Freez baby rabbit complement https://www.pel-freez.com/blogs/blog/improve-immunogenicity-testing-accuracy-with-antibody-depleted-human-complement 2026-09-19T13:03:13-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/long-blog-post-image.jpg?v=1789168468 Learn How to Improve Immunogenicity Assay Accuracy with Antibody-Depleted Complement Learn How to Improve Immunogenicity Assay Accuracy with Antibody-Depleted Complement https://www.pel-freez.com/blogs/blog/lyophilized-serum-complement 2026-09-20T13:33:18-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/researchers-vaccines.jpg?v=1789168471 You asked, we answered: Lyophilized human complement is here! You asked, we answered — Lyophilized human complement is here! https://www.pel-freez.com/blogs/blog/pel-freez-and-fda-researchers-publish-a-standardized-high-throughput-serum-bactericidal-assay-for-n-gonorrhoeae 2026-09-15T10:14:58-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/background-custom-product_2x-scaled-1.jpg?v=1789168469 A Standardized High-Throughput Serum Bactericidal Assay for N. gonorrhoeae published by Pel-Freez and FDA Researchers A Standardized High-Throughput Serum Bactericidal Assay for N. gonorrhoeae published by Pel-Freez and FDA Researchers https://www.pel-freez.com/blogs/blog/the-future-of-antibodies-in-neuroscience 2026-09-15T10:14:59-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Picture1-1-1.jpg?v=1789168481 The Future of Antibodies in Neuroscience The Future of Antibodies in Neuroscience https://www.pel-freez.com/blogs/blog/tips-for-antibody-purification 2026-09-17T10:00:15-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Picture1-4.jpg?v=1789168478 Tips for Antibody Purification Tips for Antibody Purification https://www.pel-freez.com/blogs/blog/understanding-immunoassay-development-sourcing-reagents 2026-09-15T10:18:00-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Picture1-3.jpg?v=1789168480 Understanding Immunoassay Development: Sourcing Reagents Understanding Immunoassay Development: Sourcing Reagents https://www.pel-freez.com/blogs/blog/understanding-the-clinical-significance-of-immunoglobulin-tests 2026-09-15T10:18:00-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Immunoglobulin-Tests.jpg?v=1789168479 Understanding the Clinical Significance of Immunoglobulin Tests Understanding the Clinical Significance of Immunoglobulin Tests https://www.pel-freez.com/blogs/news/join-us-at-the-2025-international-pathogenic-neisseria-conference-ipnc-in-italy 2026-09-17T10:00:15-05:00 weekly https://www.pel-freez.com/blogs/news/join-us-at-the-22nd-international-pathogenic-neisseria-conference 2026-09-15T10:18:19-05:00 weekly https://www.pel-freez.com/blogs/news/join-us-in-chicago-for-the-annual-meeting-of-the-american-association-for-clinical-chemistry-july-26-28-2022 2026-09-15T10:18:19-05:00 weekly https://www.pel-freez.com/blogs/publications/development-and-validation-of-a-standardized-human-complement-serum-bactericidal-activity-assay-to-measure-functional-an 2026-09-19T14:34:14-05:00 weekly https://www.pel-freez.com/blogs/publications/high-throughput-luminescence-based-serum-bactericidal-assay-optimization-and-characterization-to-assess-human-sera-funct 2026-09-19T14:17:47-05:00 weekly https://www.pel-freez.com/blogs/publications/an-opsonophagocytic-killing-assay-for-the-evaluation-of-group-a-streptococcus-vaccine-antisera 2026-09-19T14:17:59-05:00 weekly https://www.pel-freez.com/blogs/publications/development-of-complement-factor-h-based-immunotherapeutic-molecules-in-tobacco-plants-against-multidrug-resistant-neiss 2026-09-19T14:18:02-05:00 weekly https://www.pel-freez.com/blogs/publications/vaccination-with-detoxified-leukocidin-ab-reduces-bacterial-load-in-a-staphylococcus-aureus-minipig-deep-surgical-wound 2026-09-19T14:17:59-05:00 weekly https://www.pel-freez.com/blogs/publications/neisseria-meningitidis-urethritis-outbreak-isolates-express-a-novel-factor-h-binding-protein-variant-that-is-a-potential 2026-09-19T14:18:05-05:00 weekly https://www.pel-freez.com/blogs/publications/neuroprotection-and-immunomodulation-of-progesterone-in-the-gut-of-a-mouse-model-of-parkinson-s-disease 2026-09-19T14:18:11-05:00 weekly https://www.pel-freez.com/blogs/publications/valproic-acid-significantly-improves-crispr-cas9-mediated-gene-editing 2026-09-19T14:18:08-05:00 weekly https://www.pel-freez.com/blogs/publications/the-biochemistry-and-immunohistochemistry-of-versican 2026-09-19T14:57:02-05:00 weekly https://www.pel-freez.com/blogs/publications/physicochemical-and-biological-similarity-assessment-of-lbal-a-biosimilar-to-adalimumab-reference-product-humira 2026-09-19T14:17:57-05:00 weekly https://www.pel-freez.com/blogs/publications/biosensor-for-total-antinuclear-antibody-determination-at-the-point-of-care 2026-09-19T14:57:04-05:00 weekly https://www.pel-freez.com/blogs/publications/immunization-with-pseudomonas-aeruginosa-outer-membrane-vesicles-stimulates-protective-immunity-in-mice 2026-09-19T14:56:55-05:00 weekly https://www.pel-freez.com/blogs/publications/quality-improvement-of-capsular-polysaccharide-in-streptococcus-pneumoniae-by-purification-process-optimization 2026-09-19T14:56:46-05:00 weekly https://www.pel-freez.com/blogs/publications/age-stratified-analysis-of-serotype-specific-baseline-immunity-against-group-b-streptococcus 2026-09-19T14:18:09-05:00 weekly https://www.pel-freez.com/blogs/publications/polycationic-probe-guided-nanopore-single-molecule-counter-for-selective-mirna-detection 2026-09-19T14:18:22-05:00 weekly https://www.pel-freez.com/blogs/publications/an-investigation-of-a-possible-role-for-coenzyme-b12-in-ribonucleotide-reduction-in-rabbit-bone-marrow 2026-09-19T14:18:49-05:00 weekly https://www.pel-freez.com/blogs/publications/folate-profile-diversity-and-associated-snps-using-genome-wide-association-study-in-pea 2026-09-19T14:18:03-05:00 weekly https://www.pel-freez.com/blogs/publications/actin-bundle-architecture-and-mechanics-regulate-myosin-ii-force-generation 2026-09-19T14:56:33-05:00 weekly https://www.pel-freez.com/blogs/publications/induction-of-il-10-by-borrelia-burgdorferi-is-regulated-by-the-action-of-cd14-dependent-p38-mapk-and-camp-mediated-chrom 2026-09-19T14:18:15-05:00 weekly https://www.pel-freez.com/blogs/publications/twinfilin-bypasses-assembly-conditions-and-actin-filament-aging-to-drive-barbed-end-depolymerization 2026-09-19T14:56:48-05:00 weekly https://www.pel-freez.com/blogs/publications/actin-polymerization-is-stimulated-by-actin-cross-linking-protein-palladin 2026-09-19T14:34:53-05:00 weekly https://www.pel-freez.com/blogs/publications/analysis-of-the-effect-of-the-fluid-structure-interface-on-elastic-wave-velocity-in-cornea-like-structures-by-oce-and-fe 2026-09-19T14:18:24-05:00 weekly https://www.pel-freez.com/blogs/publications/ciprofloxacin-loaded-nanostructured-lipid-carriers-incorporated-into-in-situ-gels-to-improve-management-of-bacterial-end 2026-09-19T14:56:41-05:00 weekly https://www.pel-freez.com/blogs/publications/intrastromal-injection-of-hyaluronidase-alters-the-structural-and-biomechanical-properties-of-the-corneal-stroma 2026-09-19T14:56:45-05:00 weekly https://www.pel-freez.com/blogs/publications/ponceau-s-waste-ponceau-s-staining-for-total-protein-normalization 2026-09-19T14:18:12-05:00 weekly https://www.pel-freez.com/blogs/publications/developmental-validation-of-the-quantifiler-hp-and-trio-kits-for-human-dna-quantification-in-forensic-samples 2026-09-19T14:57:10-05:00 weekly https://www.pel-freez.com/blogs/publications/analysis-of-potential-cyanide-antidote-dimethyl-trisulfide-in-whole-blood-by-dynamic-headspace-gas-chromatography-mass-s 2026-09-19T14:18:09-05:00 weekly https://www.pel-freez.com/blogs/publications/brief-report-anti-eukaryotic-initiation-factor-2b-autoantibodies-are-associated-with-interstitial-lung-disease-in-patien 2026-09-19T14:18:25-05:00 weekly https://www.pel-freez.com/blogs/publications/pathogenic-leptospires-modulate-protein-expression-and-post-translational-modifications-in-response-to-mammalian-host-si 2026-09-19T14:18:21-05:00 weekly 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https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Male_New_Zeland_Rabbit.jpg?v=1789168742 Facts of Rabbit Complement: Infographic Facts of Rabbit Complement – Infograph https://www.pel-freez.com/blogs/blog/importance-of-human-serum-infograph 2026-09-18T07:27:33-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/Serum-Infograph.jpg?v=1789168743 Importance of Human Serum: Infographic Importance of Human Serum – Infograph https://www.pel-freez.com/blogs/blog/why-quality-and-traceability-matter-in-coagulation-reagents-for-ivd 2026-09-19T13:03:13-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/coagulation-reagents-image.jpg?v=1789168744 Why quality and traceability matter in coagulation reagents for IVD Why quality and traceability matter in coagulation reagents for IVD https://www.pel-freez.com/blogs/blog/key-attributes-of-complement-products-for-research 2026-09-21T10:45:31-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/key-attributes-of-complement-products-for-research_19e48456-cb2c-4944-9a0a-fe22e5c88f73.jpg?v=1790005531 Key Attributes of Complement Products for Research Key Attributes of Complement Products for Research https://www.pel-freez.com/blogs/blog/using-acetone-powders-for-antibody-pre-adsorption 2026-09-18T23:13:52-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/using-acetone-powders-for-antibody-pre-adsorption.jpg?v=1789485258 Using Acetone Powders for Antibody Pre-adsorption Using Acetone Powders for Antibody Pre-adsorption https://www.pel-freez.com/blogs/blog/acetone-powders-preparation-attributes-and-uses 2026-09-18T23:13:52-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/acetone-powders-preparation-attributes-and-uses.jpg?v=1789485260 Acetone Powders: Preparation, Attributes and Uses Acetone Powders: Preparation, Attributes and Uses https://www.pel-freez.com/blogs/blog/key-attributes-of-albumins-bsa-and-hsa-overview 2026-09-18T23:13:54-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/key-attributes-of-albumins-bsa-and-hsa-overview.jpg?v=1789485261 Key Attributes of Albumins: BSA and HSA Overview Key Attributes of Albumins: BSA and HSA Overview https://www.pel-freez.com/blogs/blog/albumin-purification-methods-and-fractions-explained 2026-09-18T23:13:56-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/albumin-purification-methods-and-fractions-explained.jpg?v=1789485262 Albumin Purification Methods and Fractions Explained Albumin Purification Methods and Fractions Explained https://www.pel-freez.com/blogs/blog/antibodies-in-ihc-western-blot-and-elisa-applications-and-tips 2026-09-18T23:13:57-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/antibodies-in-ihc-western-blot-and-elisa-applications-and-tips_4fba0abf-2caf-4d7b-9c7f-25349ead7d70.jpg?v=1789733415 Antibodies in IHC, Western Blot and ELISA: Applications and Tips Antibodies in IHC, Western Blot and ELISA: Applications and Tips https://www.pel-freez.com/blogs/blog/choosing-a-host-species-for-polyclonal-and-monoclonal-antibodies 2026-09-18T23:13:59-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/choosing-a-host-species-for-polyclonal-and-monoclonal-antibodies_e7019704-5b33-40e6-98a4-aefca85ea8d1.jpg?v=1789733417 Choosing a Host Species for Polyclonal and Monoclonal Antibodies Choosing a Host Species for Polyclonal and Monoclonal Antibodies https://www.pel-freez.com/blogs/blog/antibody-basics-host-target-and-isotype-explained 2026-09-19T13:03:07-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/antibody-basics-host-target-and-isotype-explained.jpg?v=1789840987 Antibody Basics: Host, Target and Isotype Explained Antibody Basics: Host, Target and Isotype Explained https://www.pel-freez.com/blogs/blog/complement-activity-explained-ch50-and-hemolytic-titer 2026-09-21T10:45:30-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/complement-activity-explained-ch50-and-hemolytic-titer_872858a4-267e-402a-98b5-797dc8116b03.jpg?v=1790005530 Complement Activity Explained: CH50 and Hemolytic Titer Complement Activity Explained: CH50 and Hemolytic Titer https://www.pel-freez.com/blogs/blog/c1q-and-factor-depleted-human-serum-dissecting-the-complement-pathways 2026-09-18T23:14:00-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/c1q-and-factor-depleted-human-serum-dissecting-the-complement-pathways.jpg?v=1789485270 C1q and Factor-Depleted Human Serum: Dissecting the Complement Pathways C1q and Factor-Depleted Human Serum: Dissecting the Complement Pathways 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https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/gamma-globulins-and-antisera-key-attributes-and-uses_e60b116c-14ec-4c14-b6f4-abe179ba8536.jpg?v=1789733427 Gamma Globulins and Antisera: Key Attributes and Uses Gamma Globulins and Antisera: Key Attributes and Uses https://www.pel-freez.com/blogs/blog/igg-purification-methods-protein-a-g-affinity-vs-ammonium-sulfate 2026-09-18T23:14:04-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/igg-purification-methods-protein-a-g-affinity-vs-ammonium-sulfate_3458dd85-0f82-4903-8dc0-8d9f77d4c8a4.jpg?v=1789733428 IgG Purification Methods: Protein A/G Affinity vs Ammonium Sulfate IgG Purification Methods: Protein A/G Affinity vs Ammonium Sulfate https://www.pel-freez.com/blogs/blog/certificates-of-analysis-for-biological-reagents-what-they-cover 2026-09-18T23:14:05-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/certificates-of-analysis-for-biological-reagents-what-they-cover.jpg?v=1789485276 Certificates of Analysis for Biological Reagents: What They Cover Certificates of Analysis for Biological Reagents: What They Cover https://www.pel-freez.com/blogs/blog/regulatory-documents-for-biological-reagents-sds-usda-permits-health-certificates 2026-09-18T23:14:05-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/regulatory-documents-for-biological-reagents-sds-usda-permits-health-certificates.jpg?v=1789485278 Regulatory Documents for Biological Reagents: SDS, USDA Permits, Health Certificates Regulatory Documents for Biological Reagents: SDS, USDA Permits, Health Certificates https://www.pel-freez.com/blogs/blog/custom-bulk-and-made-to-order-biological-reagents 2026-09-18T23:14:06-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/custom-bulk-and-made-to-order-biological-reagents.jpg?v=1789485280 Custom, Bulk and Made-to-Order Biological Reagents Custom, Bulk and Made-to-Order Biological Reagents 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https://www.pel-freez.com/blogs/publications/a-visualized-observation-of-calcium-dependent-gelsolin-activity-upon-the-surface-coverage-of-fluorescent-tagged-actin-fi 2026-09-19T14:57:17-05:00 weekly https://www.pel-freez.com/blogs/publications/acellular-vascular-grafts-generated-from-collagen-and-elastin-analogs 2026-09-19T14:18:39-05:00 weekly https://www.pel-freez.com/blogs/publications/stain-free-total-protein-staining-is-a-superior-loading-control-to-actin-for-western-blots 2026-09-19T14:57:20-05:00 weekly https://www.pel-freez.com/blogs/publications/structural-requirements-for-inhibitory-effects-of-bisphenols-on-the-activity-of-the-sarco-endoplasmic-reticulum-calcium 2026-09-19T14:57:21-05:00 weekly https://www.pel-freez.com/blogs/publications/tuning-three-dimensional-collagen-matrix-stiffness-independently-of-collagen-concentration-modulates-endothelial-cell-be 2026-09-19T14:18:44-05:00 weekly https://www.pel-freez.com/blogs/blog/inside-coagulation-screening-tests-the-reagents-behind-reliable-pt-and-aptt-results 2026-09-17T10:00:20-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/antibody-service-image.jpg?v=1789575551 Inside coagulation screening tests: The reagents behind reliable PT and aPTT results Inside coagulation screening tests: The reagents behind reliable PT and aPTT results https://www.pel-freez.com/blogs/blog/which-complement-source-for-which-assay 2026-09-21T10:45:37-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/which-complement-source-for-which-assay.jpg?v=1790005536 Which complement source for which assay? What the literature actually uses Which complement source for which assay? What the literature actually uses https://www.pel-freez.com/blogs/blog/how-to-thaw-frozen-serum 2026-09-19T13:19:02-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/hero.jpg?v=1789841942 How to thaw frozen serum: refrigerator or water bath, then aliquot How to thaw frozen serum: refrigerator or water bath, then aliquot https://www.pel-freez.com/blogs/news/tyrosine-hydroxylase-antibodies-rabbit-and-sheep-polyclonal 2026-09-19T10:13:55-05:00 weekly https://www.pel-freez.com/blogs/news/meet-pel-freez-at-adlm-2026-anaheim 2026-09-19T10:13:55-05:00 weekly https://www.pel-freez.com/blogs/news/pel-freez-at-the-vaccine-innovation-forum-shanghai-2026 2026-09-19T10:13:55-05:00 weekly https://www.pel-freez.com/blogs/news/choosing-the-right-complement-serum 2026-09-19T10:13:56-05:00 weekly https://www.pel-freez.com/blogs/news/troubleshooting-non-specific-killing-in-your-opka 2026-09-19T10:13:56-05:00 weekly https://www.pel-freez.com/blogs/news/celebrating-40-years-thomas-bise 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https://www.pel-freez.com/blogs/blog/tyrosine-hydroxylase-dopamine-pathway-bottleneck 2026-09-25T08:54:50-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/th-dopaminergic-neurons-anti-th-antibody_7524c131-8ae4-4138-bbb6-16c5e2a0102f.png?v=1790344490 The bottleneck at the start of the dopamine pathway Workflow diagram: an anti-tyrosine hydroxylase antibody applied to a mouse brain slice labels dopaminergic neurons of the substantia nigra, with a normal condition panel and a neuronal disorder panel showing reduced TH signal and neuron loss. https://www.pel-freez.com/blogs/blog/amyloid-precursor-protein-app-two-processing-routes 2026-09-21T12:55:31-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/app-processing-two-routes.png?v=1790013331 A large membrane protein with two possible fates, and only one of them makes amyloid APP processing: alpha-secretase cuts inside the amyloid-beta sequence; beta- and gamma-secretase release it intact. https://www.pel-freez.com/blogs/blog/glutamatergic-synaptic-plasticity-panel 2026-09-21T12:55:13-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/glutamatergic-synaptic-plasticity-ltp.png?v=1790013313 Long-term potentiation is not one event. It is a phosphorylation relay LTP signaling: NMDA receptor Ca2+ influx activates CaMKII, which phosphorylates AMPA receptor GluA1. https://www.pel-freez.com/blogs/blog/dat-vmat2-dopamine-transport-vesicular-storage 2026-09-21T12:54:57-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/dat-vmat2-terminal-hero_d398efd7-072d-44b9-9083-9e46de056827.png?v=1790013297 Dopamine's life after synthesis is a transport problem Dopaminergic terminal: VMAT2 packages dopamine into vesicles; DAT recovers it from the synaptic cleft. https://www.pel-freez.com/blogs/blog/marcks-myristoyl-electrostatic-switch-pkc-readout 2026-10-05T12:00:01-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/marcks-myristoyl-electrostatic-switch_dbe72313-deb5-46cf-877e-11361027c6ee.png?v=1790095471 One disordered domain, three inputs, and a switch that runs in both directions MARCKS holds PIP2 at the membrane until PKC phosphorylation neutralizes its effector domain and releases both. https://www.pel-freez.com/blogs/blog/catecholamine-cascade-aadc-dopamine-beta-hydroxylase 2026-09-28T17:00:02-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/catecholamine-biosynthesis-cascade.png?v=1790026256 Tyrosine hydroxylase marks a catecholaminergic neuron but not which catecholamine it makes The catecholamine cascade from L-tyrosine to epinephrine, with the marker combinations defining each cell identity. https://www.pel-freez.com/blogs/blog/darpp-32-thr34-thr75-striatal-signal-integration 2026-09-28T17:00:03-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/darpp32-thr34-thr75-signal-integration_7dd1062b-19b2-4f0a-a54f-f1347aeb360c.png?v=1790026915 One protein, two phosphorylation sites, opposite answers DARPP-32 as a two-way switch: phospho-Thr34 inhibits phosphatase-1, phospho-Thr75 inhibits PKA. https://www.pel-freez.com/blogs/blog/erk-p38-activation-loop-dual-phosphorylation-mapk 2026-09-28T17:00:03-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/mapk-cascade-activation-loop.png?v=1790027248 ERK and p38: two phosphates, and the antibody is the assay The three-tier MAPK cascade converging on one Thr-X-Tyr loop, inert until both residues carry a phosphate. https://www.pel-freez.com/blogs/blog/presynaptic-vesicle-cycling-synapsin-synaptotagmin 2026-10-05T12:00:01-05:00 weekly https://cdn.shopify.com/s/files/1/0815/7043/1217/articles/presynaptic-vesicle-cycling-synapsin-synaptotagmin_953c716d-77cd-464d-bcd2-071300ab618f.png?v=1790095448 The presynaptic terminal makes two decisions about release, and two proteins make them Presynaptic bouton: synapsin holds the reserve pool until phosphorylated; synaptotagmin 1 triggers fusion.