For decades Pel-Freez has been the largest US producer of rabbit blood fractions and rabbit complement. Our baby rabbit complement is used globally in serum bactericidal assays (SBA) and opsonophagocytic assays (OPA) with great success. However, our customers began expressing frustration that there was no reliable supplier when human complement when required for these assays.
We found that many of our customers were wasting valuable time and resources preparing their human complement in-house, and in 2017 we decided to develop our own platform for producing antibody depleted human complement and sera for customers. Fast forward to 2020, and we have scaled up our proprietary platform and now supply antibody depleted complement and sera to many of the world’s largest vaccine customers and CROS, who have had great success with our products.
Antibody Depleted Human Complement (ADHC)
Human complement source depleted of problematic pre-existing IgG and IgM antibodies for use in:
- Serum Bactericidal Assay
- Opsonophagocytic Assay
- C5b-9-Mediated Viral Lysis
Antibody Depleted Human Serum (ADHS)
Useful for clinical bio-functional assays as:
- IgG/IgM Negative Immunoglobulin Control Sera
- Suitable as a Diluent in Dilutional Linearity Studies
- Making Quality Control Serum Samples for Assay Acceptance Training
- Proficiency Serum Panels for Assay Qualification and
- Monitoring Long-Term Assay Performance
- Serum Panel Dilutions for Qualifying Critical Reagents
Serum is acquired from healthy donors in an FDA licensed facility who have completed informed consent prior to donation. Each donor and/or unit has been tested using FDA licensed test kits according to FDA guidelines and found to be negative for all required viral markers.
Antibody Depletion Advantage
Antibody Depletion = Low Non-Specific Strain Killing
99.5% IgG Removal
99% IgM Removal
- Improved Lot-to-Lot Consistency
- Reduced Screening Time
- Milliliter to Liter + Quantities Available
Regardless of the requirement for complement activity, all human sera, with or without antibody depletion, are off-the-clot and collected using methods that maintain optimal complement activity.
NEW IN 2020
Larger lot sizes for antibody depleted serum products:
- Serum: 3 to 5 L per Lot
- Complement: 1 to 2.5 L per Lot
As a reputable manufacturer of high-quality biological products for research in the United States, our team at Pel-Freez Biologicals is committed to providing its clients with the solutions they need for a rapidly advancing field of research. We hold an Animal Welfare Certification, as well as an ISO 9001:2015 certification.
Visit our website to purchase animal serum, plasma, complement, and ancillary products. We offer gamma globulins found in plasma function, human gamma globulin, goat gamma globulin, IgG/IgM/antibody depleted complement, adult rabbit complement, and more.